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Nerlynx (Neratinib) belongs to the class of medications called antineoplastics (anticancer medications). Specifically, it is a protein-kinase inhibitor.
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Nerlynx (Neratinib) belongs to the class of medications called antineoplastics (anticancer medications). Specifically, it is a protein-kinase inhibitor. It is taken with hormone-blocking therapy after surgery and within a year of treatment with Trastuzumab, to treat early stage Breast Cancer that is HER2-receptor positive.
Nerlynx (Neratinib) works by interfering with the growth of certain cancer cells.
Nerlynx (Neratinib) may be available under multiple brand names and/or in several different forms. Any specific brand name of Nerlynx (Neratinib) may not be available in all of the forms or approved for all of the conditions discussed here. As well, some forms of Nerlynx (Neratinib) may not be used for all of the conditions discussed here.
Your doctor may have suggested Nerlynx (Neratinib) for conditions other than those listed in these drug information articles. If you have not discussed this with your doctor or are not sure why you are taking Nerlynx (Neratinib), speak to your doctor. Do not stop taking Nerlynx (Neratinib) without consulting your doctor.
Do not give Nerlynx (Neratinib) to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take Nerlynx (Neratinib) if their doctor has not prescribed it.
The recommended adult dose of Nerlynx (Neratinib) is 240 mg (six 40 mg tablets) taken by mouth, once daily with food. It should be taken at approximately the same time every day, swallowed whole with a glass of water. Do not chew, crush, or split the tablets before taking them.
Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.
It is important to take Nerlynx (Neratinib) exactly as prescribed by your doctor.
If you miss a dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice .
Store Nerlynx (Neratinib) at room temperature, protect it from light and moisture, and keep it out of the reach of children.
Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.
Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.
The side effects listed below are not experienced by everyone who takes Nerlynx (Neratinib). If you are concerned about side effects, discuss the risks and benefits of Nerlynx (Neratinib) with your doctor.
The following side effects have been reported by at least 1% of people taking Nerlynx (Neratinib). Many of these side effects can be managed, and some may go away on their own over time.
Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.
Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not seek medical attention.
Check with your doctor as soon as possible if any of the following side effects occur:
Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking Nerlynx (Neratinib).
Each red, oval-shaped, film-coated tablet, debossed with "W104" on one side and plain on the other side, contains 40 mg of Nerlynx (Neratinib) (as 48.3 mg Nerlynx (Neratinib) maleate). Nonmedicinal ingredients: colloidal silicon dioxide, crospovidone, magnesium stearate, mannitol, microcrystalline cellulose, povidone, and purified water; film coating: iron oxide red, polyethylene glycol, polyvinyl alcohol, talc, and titanium dioxide.
Do not take Nerlynx (Neratinib) if you are allergic to Nerlynx (Neratinib) or any ingredients of the medication.
There may be an interaction between Nerlynx (Neratinib) and any of the following:
If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:
An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.
Medications other than those listed above may interact with Nerlynx (Neratinib). Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the Nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.
Before you begin using a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health.
Birth control: Women taking Nerlynx (Neratinib) should use effective birth control (e.g., condoms, birth control pill) during treatment and for at least 1 month after treatment is finished. Men who have female partners of childbearing age should use effective birth control for at least 3 months after the final dose of Nerlynx (Neratinib).
If you or your partner become pregnant during treatment with Nerlynx (Neratinib), contact your doctor immediately.
Diarrhea: Nerlynx (Neratinib) can cause diarrhea that can lead to dehydration. Dehydration can cause many symptoms, including decreased urine production, dry and sticky mouth, sleepiness, dizziness, headache, thirst, and confusion. In some cases, dehydration can become a medical emergency. Your doctor will prescribe another medication to help prevent diarrhea. If you have any questions about how to take Nerlynx (Neratinib), talk to your doctor or pharmacist.
Heart problems: Nerlynx (Neratinib) may contribute to heart problems, particularly if you have a history of a heart condition, such as Congestive Heart Failure or a past Heart Attack. If you are at risk of developing heart problems, discuss with your doctor how Nerlynx (Neratinib) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Nerlynx (Neratinib), and whether any special monitoring is needed. If you experience symptoms of heart failure, such as increased difficulty breathing, swelling in the feet and ankles, unusual tiredness or a persistent cough, contact your doctor as soon as possible.
Liver problems: Liver disease or reduced liver function may cause Nerlynx (Neratinib) to build up in the body, causing side effects. If you have liver problems, discuss with your doctor how Nerlynx (Neratinib) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Nerlynx (Neratinib), and whether any special monitoring is needed.
Nerlynx (Neratinib) can cause reduced liver function and can cause liver failure, which may be life-threatening. If you experience symptoms of liver problems such as fatigue, feeling unwell, loss of appetite, nausea, yellowing of the skin or whites of the eyes, dark urine, pale stools, abdominal pain or swelling, and itchy skin, contact your doctor immediately.
Pregnancy: Nerlynx (Neratinib) should not be used during pregnancy. If you become pregnant while taking Nerlynx (Neratinib), contact your doctor immediately.
Breast-feeding: It is not known if Nerlynx (Neratinib) passes into breast milk. If you are a breast-feeding mother and are taking Nerlynx (Neratinib), it may affect your baby. Women should not breast feed while taking Nerlynx (Neratinib) and for at least 1 month after taking the last dose.
Children: The safety and effectiveness of using Nerlynx (Neratinib) have not been established for children.
Seniors: People over the age of 65 are more likely to experience side effects from taking Nerlynx (Neratinib). Depending on how well the medication is tolerated, your doctor may reduce the dose you are taking.
References
All material © 1996-2021 MediResource Inc. Terms and conditions of use. The contents herein are for informational purposes only. Always seek the advice of your physician or other qualified health providers with any questions you may have regarding a medical condition.
December 18, 2023
December 14, 2023
August 8, 2022