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Neulasta (Pegfilgrastim) belongs to the family of medications known as granulocyte colony stimulating factors (G-CSF). Neulasta (Pegfilgrastim) helps the bone marrow produce white blood cells which help the body fight infection.
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Neulasta (Pegfilgrastim) belongs to the family of medications known as granulocyte colony stimulating factors (G-CSF). Neulasta (Pegfilgrastim) helps the bone marrow produce white blood cells which help the body fight infection.
Neulasta (Pegfilgrastim) is used to treat neutropenia (low counts of a certain type of white blood cell known as neutrophils) for people who have certain types of cancer and are receiving a type of chemotherapy that slows down white blood cell production.
Neulasta (Pegfilgrastim) may be available under multiple brand names and/or in several different forms. Any specific brand name of Neulasta (Pegfilgrastim) may not be available in all of the forms or approved for all of the conditions discussed here. As well, some forms of Neulasta (Pegfilgrastim) may not be used for all of the conditions discussed here.
Your doctor may have suggested Neulasta (Pegfilgrastim) for conditions other than those listed in these drug information articles. If you have not discussed this with your doctor or are not sure why you are taking Neulasta (Pegfilgrastim), speak to your doctor. Do not stop taking Neulasta (Pegfilgrastim) without consulting your doctor.
Do not give Neulasta (Pegfilgrastim) to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take Neulasta (Pegfilgrastim) if their doctor has not prescribed it.
The recommended adult dose of Neulasta (Pegfilgrastim) is 6 mg given by subcutaneous (under the skin) injection after each cycle of chemotherapy. Neulasta (Pegfilgrastim) should not be given less than 14 days before chemotherapy and not until 24 hours after chemotherapy.
Neulasta (Pegfilgrastim) is usually given under medical supervision. If you are giving Neulasta (Pegfilgrastim) to yourself, your doctor or health care professional will instruct you on how to use Neulasta (Pegfilgrastim) properly. It is important to use Neulasta (Pegfilgrastim) exactly as prescribed by your doctor.
If you miss a dose of Neulasta (Pegfilgrastim), call your doctor.
Many things can affect the dose of a medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.
Do not shake Neulasta (Pegfilgrastim) vigorously. Shaking Neulasta (Pegfilgrastim) damages the medication, making it less effective. Neulasta (Pegfilgrastim) should be stored in the refrigerator and protected from light. Freezing should be avoided, but if the medication is accidentally frozen, allow it to thaw in the refrigerator before being given. If the medication is accidentally frozen 2 times or is left at room temperature for more than 72 hours, it should be discarded.
Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.
Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.
The side effects listed below are not experienced by everyone who takes Neulasta (Pegfilgrastim). If you are concerned about side effects, discuss the risks and benefits of Neulasta (Pegfilgrastim) with your doctor.
The following side effects have been reported by at least 1% of people taking Neulasta (Pegfilgrastim). Many of these side effects can be managed, and some may go away on their own over time.
Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.
Although most of these side effects listed below don't happen very often, they could lead to serious problems if you do not check with your doctor or seek medical attention.
Check with your doctor as soon as possible if any of the following side effects occur:
Stop taking the medication and seek immediate medical attention if any of the following occur:
Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking Neulasta (Pegfilgrastim).
Each 0.6 mL single-use syringe of sterile, clear, colourless, preservative-free liquid for subcutaneous administration contains 6 mg of Neulasta (Pegfilgrastim) (based on protein mass only). Nonmedicinal ingredients: polysorbate 20, sodium acetate, sorbitol, and water for injection, USP; pH: 4.0. The needle cover on the prefilled syringe contains dry natural rubber (a derivative of latex).
Do not take Neulasta (Pegfilgrastim) if you:
There may be an interaction between Neulasta (Pegfilgrastim) and any of the following:
If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:
An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.
Medications other than those listed above may interact with Neulasta (Pegfilgrastim). Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the Nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.
Before you begin using a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use Neulasta (Pegfilgrastim).
Capillary leak syndrome (CLS): Capillary leak syndrome been experienced by people using Neulasta (Pegfilgrastim). This is a condition where blood leaks from the small blood vessels, into your body. CLS can cause severely decreased blood pressure and may be life threatening. If you experience symptoms of CLS, such as swelling or puffiness, difficulty breathing, abdominal swelling, tiredness, feeling of fullness, seek immediate medical attention.
Cytotoxic chemotherapy: The safety of using Neulasta (Pegfilgrastim) at the same time as cytotoxic chemotherapy (a type of chemotherapy that kills cells, especially cancer cells) has not been established. Neulasta (Pegfilgrastim) should not be used within 14 days before or 24 hours after chemotherapy. In addition, it is not known whether it is safe and effective to use Neulasta (Pegfilgrastim) after certain chemotherapy medications (e.g., Mitomycin C, 5-fluorouracil, and nitrosoureas such as carmustine and lomustine).
Ruptured spleen: In rare cases, Neulasta (Pegfilgrastim) has been reported to cause the spleen to rupture, which can be fatal. The spleen is an organ in the body that is involved in the production and removal of blood cells. If you have pain in the left upper stomach or left shoulder tip area, contact your doctor immediately.
Lung problems: Neulasta (Pegfilgrastim) may cause adult respiratory distress syndrome (ARDS), a serious lung condition, when people with neutropenia have sepsis (bacterial infection in the blood). If ARDS occurs, Neulasta (Pegfilgrastim) should be stopped until the ARDS resolves.
Radiation: It is not known whether it is safe and effective to use Neulasta (Pegfilgrastim) with radiation therapy. Neulasta (Pegfilgrastim) should not be used during radiation therapy.
Sickle cell disease: Neulasta (Pegfilgrastim) may cause sickle cell crisis when used by people who have sickle cell disease. You and your doctor should carefully consider the benefits and risks of using Neulasta (Pegfilgrastim) in these circumstances.
Pregnancy: Neulasta (Pegfilgrastim) should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking Neulasta (Pegfilgrastim), stop taking it immediately and call your doctor.
Breast-feeding: It is not known whether Neulasta (Pegfilgrastim) passes into breast milk. If you are a breast-feeding mother and are taking Neulasta (Pegfilgrastim), it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.
Children: The safety and effectiveness of Neulasta (Pegfilgrastim) have not been established for children.
References
All material © 1996-2021 MediResource Inc. Terms and conditions of use. The contents herein are for informational purposes only. Always seek the advice of your physician or other qualified health providers with any questions you may have regarding a medical condition.
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