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Odomzo (Sonidegib) belongs to the class of medications called antineoplastic agents. It is used to treat locally advanced basal cell carcinoma, a type of Skin Cancer, when it cannot be treated with surgery or radiation.
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Odomzo (Sonidegib) belongs to the class of medications called antineoplastic agents. It is used to treat locally advanced basal cell carcinoma, a type of Skin Cancer, when it cannot be treated with surgery or radiation. Odomzo (Sonidegib) works by blocking a protein involved in signaling the growth of cancer cells.
Odomzo (Sonidegib) may be available under multiple brand names and/or in several different forms. Any specific brand name of Odomzo (Sonidegib) may not be available in all of the forms or approved for all of the conditions discussed here. As well, some forms of Odomzo (Sonidegib) may not be used for all of the conditions discussed here.
Your doctor may have suggested Odomzo (Sonidegib) for conditions other than those listed in these drug information articles. If you have not discussed this with your doctor or are not sure why you are taking Odomzo (Sonidegib), speak to your doctor. Do not stop taking Odomzo (Sonidegib) without consulting your doctor.
Do not give Odomzo (Sonidegib) to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take Odomzo (Sonidegib) if their doctor has not prescribed it.
The recommended adult dose of Odomzo (Sonidegib) is 200 mg taken by mouth once daily, on an empty stomach, either 1 hour before or 2 hours after a meal.
Swallow the capsules whole with some water. Do not open, crush, or chew the capsules. Do not take this mediation with grapefruit juice or Seville oranges or juice.
Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.
It is important to take Odomzo (Sonidegib) exactly as prescribed by your doctor. If you vomit after taking a dose, do not take another dose. Take the next dose as scheduled.
If you miss a dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.
Store Odomzo (Sonidegib) at room temperature, protect it from light and moisture, and keep it out of the reach of children.
Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.
Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.
The side effects listed below are not experienced by everyone who takes Odomzo (Sonidegib). If you are concerned about side effects, discuss the risks and benefits of Odomzo (Sonidegib) with your doctor.
The following side effects have been reported by at least 1% of people taking Odomzo (Sonidegib). Many of these side effects can be managed, and some may go away on their own over time.
Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.
Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not seek medical attention.
Check with your doctor as soon as possible if any of the following side effects occur:
Stop taking the medication and seek immediate medical attention if any of the following occur:
Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking Odomzo (Sonidegib).
Each opaque pink capsule with "Odomzo (Sonidegib) 200MG" printed on the capsule body and "NVR" printed on the cap in black ink, contains 200 mg of Odomzo (Sonidegib). Nonmedicinal ingredients: colloidal silicon dioxide, crospovidone, lactose monohydrate, magnesium stearate, poloxamer, and sodium lauryl sulfate; hard-capsule shell: gelatin, red iron oxide, and titanium dioxide; printing ink: ammonium hydroxide, black iron oxide, propylene glycol, and shellac.
Do not take Odomzo (Sonidegib) if you:
Do not give Odomzo (Sonidegib) to children or adolescents under the age of 18.
There may be an interaction between Odomzo (Sonidegib) and any of the following:
If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:
An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.
Medications other than those listed above may interact with Odomzo (Sonidegib). Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the Nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.
Before you begin using a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use Odomzo (Sonidegib).
Birth control: Odomzo (Sonidegib) appears in the sperm of men taking Odomzo (Sonidegib). To protect your partner, as well as prevent pregnancy, all men who are taking Odomzo (Sonidegib) and have a partner who could become pregnant must use a condom while taking the medication and for 6 months after the last dose.
Women who are taking Odomzo (Sonidegib) must use 2 reliable forms of birth control, beginning at least 4 weeks before starting Odomzo (Sonidegib), while taking Odomzo (Sonidegib), and for 20 months after the last dose. At least one of these methods must be a highly effective method of birth control and one must be a barrier method, such as condom or diaphragm with spermicide.
Your doctor will have you do a pregnancy test monthly starting the week before the first dose of the medication, while you are taking Odomzo (Sonidegib), and for 20 months after the last dose.
Blood donation: Avoid donating blood for at least 20 months after taking the last dose of Odomzo (Sonidegib).
Liver function:Â Liver disease or reduced liver function may cause Odomzo (Sonidegib) to build up in the body, causing side effects. If you have liver problems, discuss with your doctor how Odomzo (Sonidegib) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Odomzo (Sonidegib), and whether any special monitoring is needed.
Muscle effects: Muscle damage has been associated with the use of Odomzo (Sonidegib). Report any unexplained muscle pain, tenderness, weakness, or cramps, or any brown or discoloured urine to your doctor immediately, particularly if you are also experiencing malaise (a general feeling of being unwell) or Fever.
Other cancers: There have been reports of squamous cell carcinoma, another form of skin cancer, developing after taking Odomzo (Sonidegib). This type of skin cancer may appear as scaly red patches; open sores; or rough, thickened, or wart-like skin. It may also appear as raised growths on the skin. Report any changes to your skin to your doctor as soon as possible.
Pregnancy: Odomzo (Sonidegib) can cause severe birth defects affecting the baby if the mother takes Odomzo (Sonidegib) during pregnancy. Two forms of effective birth control must be used while taking Odomzo (Sonidegib) and for 20 months after the last dose. If you become pregnant while taking Odomzo (Sonidegib), contact your doctor immediately.
Breast-feeding: It is not known if Odomzo (Sonidegib) passes into breast milk. If you are breast-feeding and are taking Odomzo (Sonidegib), it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.
Children: The safety and effectiveness of using Odomzo (Sonidegib) have not been established for children.
Seniors: It is likely that people over the age of 65 will experience more side effects and more severe side effects.
References
All material © 1996-2021 MediResource Inc. Terms and conditions of use. The contents herein are for informational purposes only. Always seek the advice of your physician or other qualified health providers with any questions you may have regarding a medical condition.
December 18, 2023
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